Researcher 4
Location: Minneapolis-Saint Paul, Minnesota
Description: University of Minnesota is presently looking of Researcher 4 right now, this vacancy will be assigned in Minnesota. Detailed specification about this vacancy opportunity kindly see the descriptions. Qualifications
Required Qualifications: ALL REQUIRED QUALIFICATIONS MUST BE DOCUMENTED ON APPLICATION MATERIALS > Bachelor’s degree or equivalent in a scientific discipline, AALAC training as a Laboratory Animal Technologist and a mini mum of 5 years of experience working with a large, complex mouse colony. Necessary skills include mouse colony management, ability to design and implement preclinical studies to test novel compounds, drug administration (IM, IP, IV, oral gavage), blood collection, behavioral experiments, surgeries, health evaluations, animal imaging and necropsies including perfusion fixation. Molecular biology skills including DNA and RNA isolation, PCR, ELISA and mammalian cell culture are required.
Preferred Qualifications:
Special consideration will be given to applicants with experience in the isolation and culture of primary mammalian cells. The ideal candidate will have strong problem-solving skills and the ability to maintain responsibility for multiple projects simultaneously. An ability and willingness to train others in animal experimentation is desirable.
About the Job
Summary of Position:
This individual will take primary responsi bility for maintaining the laboratory mouse colony. This involves setting-up breedings to generate hundreds of different transgenic lines, weaning, earing, genotyping and organizing animals into experimental cohorts. The individual will be responsible for conducting genetic and pharmacologic studies aimed at impacting healthspan and lifespan. This includes measuring numerous functional, clinical and behavioral endpoints longitudinally in mice to determine their health status, as well as animal imaging. It also includes taking responsibility for organizing and performing large necropsies of mice to collect biological samples and distribute these samples amongst collaborators and our tissuebank. The candidate will be responsible for writing animal protocols, managing imports and exports, and examining the literature for state-of-the-art practices for measuring molecular and functional endpoints in mice. The individual must use our mouse cloud database to generate specimen labe ls and enter data. Preparation of tissue lysates, isolation of nucleic acids and protein, PCR, qRT-PCR, electrophoresis, ELISA, immunoblotting. Primary cell culture. Animal surgeries. Data analysis and contributing methods and figures to manuscripts and grant applications. Instruct others in all of the above practices and to create laboratory SOPs.
ESSENTIAL DUTIES:
70% Pre-clinical studies in mice (essential)
Design and implement genetic and pharmacologic studies aimed at testing hypotheses about fundamental mechanisms of aging. This includes management of a highly complex mouse colony with over 100 strains of mice, creating complex breeding schemes to obtain novel strains of experimental mice, quantitatively evaluating the health/frailty of live animals, designing and implementing serial behavioral and imaging studies, surgical techniques including stereotactic injections and parabiosis, organizing and leading mouse necropsies on large cohorts of an imals, collection and proper preservation of mouse tissues and bodily fluids, calculate dosing and the administration of drugs and special diets. Ordering all drugs, diets, specialized equipment and disposables needed to execute animal experiments.
10% Molecular biology (essential)
Mammalian cell culture, preparation of cell and tissue lysates, isolate DNA, RNA and protein, quantitate nucleic acids and protein levels, perform PCR genotyping, nucleic acid and protein electrophoresis, ELISAs.
10% Sample Management (essential)
Independently iteract with members of large programmatic grants, sponsored research agreements and collaborators to collate lists of biological samples needed. Supervise collection of all biological samples from pre-clinical mouse studies. Organize and execute distribution of biological samples to collaborators world-wide. Interface with our independent contractor to improve the workflow of sample management via the MouseCloud Da tabase.
10% Data Management (essential)
Supervise the entry of primary data into the MouseCloud Database. Analyse molecular biology and animal experimentation data. Provide methods and figures from this data for manuscripts and grants. Interface with our independent contractor to improve the workflow of data management and sharing via the MouseCloud Database.
About the Department
The department of Biochemistry, Molecular Biology and Biophysics is committed to understanding the molecular mechanisms of metabolic diseases and cancer; developing novel strategies in biocatalysis and biotechnology; and advancing knowledge through structural biology and molecular biophysics. We organize ourselves into research divisions with emphases on Chemical and Structural Biology , Metabolic and Systems Biology , Molecular Biology and Synthetic Biology and Biotechnology . We are housed in new buildings with state-of-the-art research and support facilities.
How To Apply
Applications must be submitted online. To be considered for this position, please click the Apply button and follow the instructions. You will be given the opportunity to complete an online application for the position and attach a cover letter and resume. BOTH REQUIRED.
Additional documents may be attached after application by accessing your "My Activities" page and uploading documents there.
To request an accommodation during the application process, please e-mail employ@umn.edu or call (612) 624-UOHR (8647).
Diversity
The University recognizes and values the importance of diversity and inclusion in enriching the employment experience of its employees and in supporting the academic mission. The University is committed to attracting and retaining employees with varying identities and backgrounds.
The University of Minnesota provides equal access to and opportunity in its programs, facilities, and employment without rega rd to race, color, creed, religion, national origin, gender, age, marital status, disability, public assistance status, veteran status, sexual orientation, gender identity, or gender expression. To learn more about diversity at the U: http://diversity.umn.edu.
Background Check Information
Any offer of employment is contingent upon the successful completion of a background check. Our presumption is that prospective employees are eligible to work here. Criminal convictions do not automatically disqualify finalists from employment.
About the U of M
The University of Minnesota, Twin Cities (UMTC)
The University of Minnesota, Twin Cities (UMTC), is among the largest public research universities in the country, offering undergraduate, graduate, and professional students a multitude of opportunities for study and research. Located at the heart of one of the nation's most vibrant, diverse metropolitan communities, students on the campuses in M inneapolis and St. Paul benefit from extensive partnerships with world-renowned health centers, international corporations, government agencies, and arts, nonprofit, and public service organizations.
- .
If you were eligible to this vacancy, please give us your resume, with salary requirements and a resume to University of Minnesota.
See example of canadian resume sample here.
Interested on this vacancy, just click on the Apply button, you will be redirected to the official website
This vacancy will be started on: Mon, 07 May 2018 23:51:12 GMT